The Metabolic Syndrome State of the Art Symposium

Document Actions

October 23, 2004-10-20
San Clemente Palace • Isola di San Clemente
San Marco • 30124 Venice • Italy

--> Programme : PDF - 143 kb, PPT - 692 kb

CHAIRMAN: Paul Zimmet: Opening remarks and meeting objectives
P. Zimmet
Overview: The Metabolic Syndrome - an evolving concept
History of ATPIII, WHO and AACE criteria
S.M. Grundy

The Metabolic Syndrome – current criteria
Feedback from May 2004 IDF workshop
: PAUL ZIMMET
INTERNATIONAL DIABETES INSTITUTE, MELBOURNE, AUSTRALIA
An important aspect of the interest raised by the metabolic syndrome has been to bring together workers from the diabetes and cardiovascular research fields. A recent and significant contribution of diabetologists has been to propose a revised version of the NCEP-ATP III criteria, which may make abdominal obesity the core component of the metabolic syndrome. An advantage of this revised definition is that it could be used for various ethnic groups and populations of the world.
Introduction
Download video [MPEG / WMV]
Reversing the Controversy on Criteria
Downoad video The Metabolic Syndrome [MPEG / WMV]
Download [PPT - 2Mb]

The Metabolic Syndrome Institute background, purpose and activities
P. Barter (PPT - 1.2Mb)
Pathophysiology: Insulin resistance
GAETANO CREPALDI
DEPARTMENT OF MEDICAL AND SURGICAL SCIENCES, UNIVERSITY OF PADOVA, ITALY
As early as 1967, G. Crepaldi et al identified a state of insulin resistance in moderately obese patients with impaired fasting glucose and high triglyceride levels. Insulin resistance is a core feature of the metabolic syndrome and may lead, through various mechanisms, to atherosclerosis and cardiovascular events.
Pathophysiology-Insulin resistance
Download video [MPEG / WMV]
Download [PPT - 2.8 Mb]

Inflammation
P. Libby

Ethnic differences and pro-thrombotic states
S. Anand (PPT - 727 kb)

Psychological stress
K. Raikkonen - Slide show

Hypertension
STEVO JULIUS
UNIVERSITY OF MICHIGAN MEDICAL CENTER, ANN ARBOR, USA
Why hypertension aggregates with metabolic risk factors in people with the metabolic syndrome is a research issue. Data from experimental studies and intervention trials suggest that the enhanced sympathetic tone already present in the early stages of hypertension facilitates the emergence of a state of insulin resistance, and hence of the metabolic syndrome.
Metabolic Syndrome Clinical Importance
Download video [MPG / WMV]
Download [PPT - 1.4 Mb]

CHAIRMAN: Rury Holman)
Clinical practice: Lipid perspective
M.-R. Taskinen (PPT - 2.6 Mb)

Cardiological perspective
R. Nesto (PPt - 708 kb)

Diabetic perspective
P. Zimmet

Obesity perspective
Y. Matsuzawa (PPT - 4 Mb)"

Insulin resistance perspective
E. Ferrannini
Management: Diet and physical activity
FRANK SACKS
HARVARD SCHOOL OF PUBLIC HEALTH; AND BRIGHAM AND WOMEN’S HOSPITAL, HARVARD MEDICAL SCHOOL, BOSTON, USA
A healthy diet can make a big improvement in all components of the metabolic syndrome. For hypertension, a diet high in whole grains, nuts, fruits and vegetables, with low salt is highly effective, as is a Mediterranean diet. To improve dyslipidaemia with low HDL and high triglyceride, unsaturated fats rather than carbohydrates are most beneficial. Finally, the optimal diet for weight loss, whether rich in protein, unsaturated fat or carbohydrate, is being studied intensively in several randomised trials.
Dietary Approaches to Management of Metabolic Syndrome
Download video [MPEG / WMV]
Download [Slide show]
Final words: Wrap up of the day and future steps
P. Barter