A diagnosis of metabolic syndrome provides additional prediction of cardiovascular disease and total mortality in the elderly
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This study was aimed to assess whether a diagnosis of metabolic syndrome improved the prediction of cardiovascular disease and total mortality beyond that provided by conventional risk factors. In a longitudinal cohort study, 2805 subjects of both sexes (aged 60 years or more) and living in the New South Wales community of Dubbo were first assessed in 1988-1989 and followed-up for 16 years for coronary heart disease (CHD) events, ischaemic stroke events and total mortality. In proportional hazards models including conventional risk factors but excluding variables used to define the presence of metabolic syndrome, the metabolic syndrome was a significant predictor of CHD, stroke and total mortality: the respective hazard ratios were 1.64, 1.31 and 1.53 in men and 1.70, 1.37 and 1.35 in women, respectively. The authors conclude that a diagnosis of metabolic syndrome provides useful additional prediction of CHD events, stroke events, and total mortality beyond that provided by other conventional risk factors, and that ascertaining the presence of a metabolic syndrome may prove useful in clinical management.
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