Increases in causal blood glucose, even within the normal range, predict cardiovascular disease mortality
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A representative cohort of the Japanese population including 9,444 subjects was followed-up over 17.3 years in order to clarify whether high non-fasting, casual blood glucose (CBG) can predict cardiovascular disease mortality. CBG groups were defined as follows: high CBG≥11.1 mmol/L or subjects with a history of diabetes mellitus; borderline high 7.77≤CBG<11.1 mmol/L; higher normal 5.22≤CBG<7.77 mmol/L and lower normal CBG<5.22 mmol/L. After adjusting for age and sex, the hazard ratios (HRs) for coronary heart disease (CHD) mortality were 2.62 and 2.43 in high and borderline high CBG groups respectively, with similar results observed for CVD and all-cause mortality. Even within the normal blood glucose range, each 1 mmol/L increase in CBG was associated with a statistically significant increase in the HR for CVD mortality. These results demonstrate that increases in CBG, even within the normal range, predict CVD mortality in Japanese subjects.
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