Nondipping pattern in ambulatory blood pressure monitoring as an independent predictor of glucose intolerance

A reduction in nocturnal blood pressure decline (<10% from daytime systolic blood pressure [SBP] during 24-h ambulatory blood pressure monitoring [ABPM]) has been associated with increased cardiovascular morbidity. This cross-sectional, population-based study was designed to assess whether ABPM characteristics were associated with metabolic abnormalities in subjects without hypertension or type 2 diabetes. Results suggested that 24-h ABPM nondippers were more obese and presented with higher very-low-density lipoprotein (VLDL) cholesterol, total triglycerides, VLDL-triglycerides, and oral glucose tolerance test 2-h blood glucose as compared to subjects with dipping in 24-h ABPM. Nondipping status was encountered more frequently among subjects with metabolic syndrome, impaired glucose tolerance (IGT), and in those with combined IGT and type 2 diabetes than in subjects without these abnormalities. Multivariate model analysis revealed that ABPM nondipping status was an independent predictor of IGT. The authors conclude that ABPM nondipping status is an independent predictor of glucose intolerance, and associates with several other metabolic abnormalities.

Abstract

Keywords:
Blood pressure – Dyslipidaemia – HDL cholesterol – IDF definition – IGT – NCEP ATP III definition – Triglycerides – VLDL