No relationship between metabolic syndrome and bone mineral density in a population-based US study
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The pro-inflammatory state associated with the metabolic syndrome may lead to a reduction in bone mass. On the other hand, elevated body mass index exerts a protective effect against osteoporosis. The aim of the study was to evaluate the association between metabolic syndrome and bone mineral density (BMD). To this end, a cross-sectional analysis of femoral neck BMD (FN-BMD) was conducted for 8197 subjects from the Third National Health and Nutrition Examination Survey, with and without metabolic syndrome. Among this study population, 1773 subjects (22%) had the metabolic syndrome. Compared to subjects without the metabolic syndrome, subjects with the metabolic syndrome had higher FN-BMD (P<0.0001) after adjusting for multiple variables. After stratification by BMI, FN-BMD was similar between subjects with and without the metabolic syndrome, whereas adjusted FN-BMD increased with additional components of the metabolic syndrome (P<0.0001 for trend), the association with abdominal obesity being significant (P<0.0001). Therefore, the metabolic syndrome is not associated with reduced FN-BMD in this population-based cross-sectional study. Among subjects with the metabolic syndrome, obesity appeared to be the major component increasing BMD.
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