The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Adipose Tissue

• Visceral adipose tissue specific persistence of Mycobacterium tuberculosis may be reason for the metabolic syndrome.
  (Erol A. Med Hypotheses. 2008 Aug;71(2):222-8. Epub 2008 Apr 29.)
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• A relationship between echocardiographic subepicardial adipose tissue and metabolic syndrome.
  (Okyay K, et al. Int J Cardiovasc Imaging. 2008 Aug;24(6):577-83. Epub 2008 Jan 26.)
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Apo / Lipoproteins

• Non-high density lipoprotein cholesterol in patients with metabolic syndrome.
  (Huang J, et al. J Investig Med. 2008 Aug 26. [Epub ahead of print])
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Assessment & Treatment

• A practical "ABCDE" approach to the metabolic syndrome.
  (Blaha MJ, et al. Mayo Clin Proc. 2008 Aug;83(8):932-41. Review.)
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Biomarkers

• A-FABP--a biomarker associated with the metabolic syndrome and/or an indicator of weight change?
  (Engl J, et al. Obesity (Silver Spring). 2008 Aug;16(8):1838-42. Epub 2008 May 29.)
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• Thrombotic markers in metabolic syndrome subjects exposed to diesel exhaust.
  (Carlsten C, et al. Inhal Toxicol. 2008 Aug;20(10):917-21.)
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• Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome.
  (Gómez Rosso L, et al. Atherosclerosis. 2008 Aug;199(2):415-23. Epub 2007 Dec 21.)
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Cardiovascular Disease

• Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: the Northern Manhattan Study (NOMAS).
  (Suzuki T, et al. Am Heart J. 2008 Aug;156(2):405-10. Epub 2008 May 27.)
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• The effects of pre-disease risk factors within metabolic syndrome on all-cause and cardiovascular disease mortality.
  (Tsai SP, et al. Diabetes Res Clin Pract. 2008 Aug 29. [Epub ahead of print])
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• Intravascular kinetics of C-reactive protein and their relationships with features of the metabolic syndrome.
  (Mauger JF, et al. J Clin Endocrinol Metab. 2008 Aug;93(8):3158-64. Epub 2008 May 20.)
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• Does diagnosis of metabolic syndrome predict the likelihood of peripheral arterial disease as defined by a low ankle-brachial index?
  (López-Suárez A, et al. Eur J Cardiovasc Prev Rehabil. 2008 Aug 27. [Epub ahead of print])
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• Comparison of serum lipid values in subjects with and without the metabolic syndrome.
  (Cordero A, et al. Am J Cardiol. 2008 Aug 15;102(4):424-8.)
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• Metabolic syndrome and left ventricular dysfunction: New player of the game.
  (Celik T, et al. Int J Cardiol. 2008 Aug 1. [Epub ahead of print])
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Diabetes

• Cardiovascular risk factors characteristic for the metabolic syndrome in adult patients with type 1 diabetes.
  (Nádas J, et al. Exp Clin Endocrinol Diabetes. 2008 Aug 25. [Epub ahead of print])
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• High-sensitivity C-reactive protein and the hypertriglyceridemic waist in patients with type 2 diabetes and metabolic syndrome.
  (Rosolova H, et al. Med Sci Monit. 2008 Aug;14(8):CR411-5.)
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• One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes.
  (Abdul-Ghani MA, et al. Diabetes Care. 2008 Aug;31(8):1650-5. Epub 2008 May 16.)
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• Association between body mass index and core components of metabolic syndrome in 1486 patients with type 1 diabetes mellitus in Japan (JDDM 13).
  (Arai K, et al. Endocr J. 2008 Aug 28. [Epub ahead of print])
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• The metabolic syndrome as a tool for predicting future diabetes: the AusDiab study.
  (Cameron AJ, et al. J Intern Med. 2008 Aug;264(2):177-86. Epub 2008 Feb 20.)
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• Prevalence of diabetes mellitus and metabolic syndrome in Slovakia.
  (Mokán M, et al. Diabetes Res Clin Pract. 2008 Aug;81(2):238-42. Epub 2008 May 20.)
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Diet, Nutrition & Metabolism

• Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease.
  (Pasinetti GM, et al. J Neurochem. 2008 Aug;106(4):1503-14. Epub 2008 May 3.)
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• Dietary management of the metabolic syndrome beyond macronutrients.
  (Minich DM, et al. Nutr Rev. 2008 Aug;66(8):429-44.)
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• Carbohydrate restriction as the default treatment for type 2 diabetes and metabolic syndrome.
  (Feinman RD, et al. Scand Cardiovasc J. 2008 Aug;42(4):256-63.)
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• The association between dietary macronutrient intake and the prevalence of the metabolic syndrome.
  (Skilton MR, et al. Br J Nutr. 2008 Aug;100(2):400-7. Epub 2008 Jan 15.)
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Drug Therapy

• Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto study.
  (Meaney E, et al. Clin Exp Pharmacol Physiol. 2008 Aug;35(8):895-903. Epub 2008 Mar 13.)
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• The effects of low-dose simvastatin and ezetimibe compared to high-dose simvastatin alone on post-fat load endothelial function in patients with metabolic syndrome: a randomized double-blind crossover trial.
  (Olijhoek JK, et al. J Cardiovasc Pharmacol. 2008 Aug;52(2):145-50.)
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• Dose-dependent effect of rosuvastatin on VLDL-apolipoprotein C-III kinetics in the metabolic syndrome.
  (Ooi EM, et al. Diabetes Care. 2008 Aug;31(8):1656-61. Epub 2008 May 28.)
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• Comparison effect of atorvastatin (10 versus 80 mg) on biomarkers of inflammation and oxidative stress in subjects with metabolic syndrome.
  (Singh U, et al. Am J Cardiol. 2008 Aug 1;102(3):321-5. Epub 2008 May 28.)
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• The effect of antipsychotic medication on metabolic syndrome.
  (Jones M, et al. Nurs Stand. 2008 Aug 6-12;22(48):43-8.)
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Epidemiology

• Waist circumference, metabolic syndrome and coronary artery disease in a Pakistani cohort.
  (Wierzbicki AS, et al. Int J Cardiol. 2008 Aug 1;128(1):77-82. Epub 2007 Aug 8.)
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• Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: A study of Korean adults.
  (Kang YH, et al. Endocr J. 2008 Aug 28. [Epub ahead of print])
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• C-reactive protein, metabolic syndrome and incidence of severe hip and knee osteoarthritis. A population-based cohort study.
  (Engström G, et al. Osteoarthritis Cartilage. 2008 Aug 28. [Epub ahead of print])
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• Prevalence of metabolic syndrome and associated risk factors in Asian Indians.
  (Balasubramanyam A, et al. J Immigr Minor Health. 2008 Aug;10(4):313-23.)
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• C-reactive protein and the metabolic syndrome correlate differently with carotid atherosclerosis between men and women in a Taiwanese community.
  (Chen PC, et al. Metabolism. 2008 Aug;57(8):1023-8.)
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• The metabolic syndrome and mortality: the Singapore Cardiovascular Cohort Study.
  (Lee J, et al. Clin Endocrinol (Oxf). 2008 Aug;69(2):225-30. Epub 2008 Jan 15.)
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• Self-reported prevalence and awareness of metabolic syndrome: findings from SHIELD.
  (Lewis SJ, et al. Int J Clin Pract. 2008 Aug;62(8):1168-76. Epub 2008 Apr 29.)
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Exercise / Physical Activity

• The longitudinal effects of physical activity history on metabolic syndrome.
  (Yang X, et al. Med Sci Sports Exerc. 2008 Aug;40(8):1424-31.)
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• Gentle exercise of 40 minutes with dietary counseling is effective in treating metabolic syndrome.
  (Mitsui T, et al. Tohoku J Exp Med. 2008 Aug;215(4):355-61.)
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Genetics

• FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome.
  (Attaoua R, et al. Biochem Biophys Res Commun. 2008 Aug 22;373(2):230-4. Epub 2008 Jun 20.)
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• Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population.
  (Carter KW, et al. Hum Genet. 2008 Aug 21. [Epub ahead of print])
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• Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.
  (Wallis RH, et al. PLoS ONE. 2008 Aug 13;3(8):e2962.)
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• Genotypes and haplotypes of beta2-adrenergic receptor and parameters of the metabolic syndrome in Korean adolescents.
  (Park HS, et al. Metabolism. 2008 Aug;57(8):1064-70.)
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• Overexpression of TRB3 gene in adipose tissue of rats with high fructose-induced metabolic syndrome.
  (Bi XP, et al. Endocr J. 2008 Aug;55(4):747-52. Epub 2008 May 23.)
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• The association of endothelial nitric oxide synthase G894T polymorphism with C-reactive protein level and metabolic syndrome in a Chinese study group.
  (Hsieh MC, et al. Metabolism. 2008 Aug;57(8):1125-9.)
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• Gene-environment interactions and susceptibility to metabolic syndrome and other chronic diseases.
  (Ordovas JM, et al. J Periodontol. 2008 Aug;79(8 Suppl):1508-13.)
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• Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease.
  (Powell BL, et al. Hum Genet. 2008 Aug 30. [Epub ahead of print])
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• Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in non-diabetic caucasians.
  (Qasim AN, et al. Clin Endocrinol (Oxf). 2008 Aug 15. [Epub ahead of print])
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• Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study.
  (de Mello VD, et al. Diabetologia. 2008 Aug 30. [Epub ahead of print])
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Hypertension

• Long-term risk of diabetes, hypertension and left ventricular hypertrophy associated with the metabolic syndrome in a general population.
  (Mancia G, et al. J Hypertens. 2008 Aug;26(8):1602-11.)
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• Predictive value of prehypertension for metabolic syndrome, diabetes, and coronary heart disease among turks.
  (Onat A, et al. Am J Hypertens. 2008 Aug;21(8):890-5. Epub 2008 Jun 12.)
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Insulin Resistance / Insulin Sensitivity

• Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese.
  (Qi Q, et al. Eur J Endocrinol. 2008 Aug 27. [Epub ahead of print])
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• ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome.
  (Iizuka K, et al. Endocr J. 2008 Aug;55(4):617-24. Epub 2008 May 19.)
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Metabolic Syndrome and Kidney Function

• Clinical study of the risk factors of insulin resistance and metabolic syndrome after kidney transplantation.
  (Sui W, et al. Transpl Immunol. 2008 Aug 12. [Epub ahead of print])
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• An association between metabolic syndrome and the estimated glomerular filtration rate.
  (Kawamoto R, et al. Intern Med. 2008;47(15):1399-406. Epub 2008 Aug 1.)
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• Role for the urinary bladder in pathogenesis of metabolic syndrome in Wistar rats.
  (Balasubramanian T. Singapore Med J. 2008 Aug;49(8):644-9.)
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Metabolic Syndrome in Men

• Metabolic syndrome, testosterone deficiency and erectile dysfunction never come alone.
  (Yassin AA, et al. Andrologia. 2008 Aug;40(4):259-64.)
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• The association between metabolic syndrome and prostate-specific antigen levels.
  (Kim YJ, et al. Int J Urol. 2008 Aug 20. [Epub ahead of print])
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• Relationship between serum prostate-specific antigen levels and components of metabolic syndrome in healthy men.
  (Han JH, et al. Urology. 2008 Aug 11. [Epub ahead of print])
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Metabolic Syndrome in Women

• High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offspring.
  (Szeto IM, et al. Am J Physiol Regul Integr Comp Physiol. 2008 Aug;295(2):R575-82. Epub 2008 Jun 4.)
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• Red clover extract: a putative source for simultaneous treatment of menopausal disorders and the metabolic syndrome.
  (Mueller M, et al. Menopause. 2008 Aug 21. [Epub ahead of print])
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• Clinical spectrum of premature pubarche: Links to metabolic syndrome and ovarian hyperandrogenism.
  (Ibáñez L, et al. Rev Endocr Metab Disord. 2008 Aug 26. [Epub ahead of print])
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• Transient prenatal androgen exposure produces metabolic syndrome in adult female rats.
  (Demissie M, et al. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E262-8. Epub 2008 Jun 10.)
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• Educational and organizational interventions used to improve the knowledge of metabolic syndrome among postmenopausal women.
  (Barriga J, et al. Fertil Steril. 2008 Aug;90(2):444-6. Epub 2007 Nov 5.)
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• Evaluation of metabolic syndrome risk in Korean premenopausal women: not waist circumference but visceral fat.
  (Hyun YJ, et al. Circ J. 2008 Aug;72(8):1308-15.)
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Non-Alcoholic Fatty Liver Disease

• Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease.
  (Chen ZW, et al. J Zhejiang Univ Sci B. 2008 Aug;9(8):616-22.)
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• Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss.
  (Reinehr T, et al. J Clin Endocrinol Metab. 2008 Aug 26. [Epub ahead of print])
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Obesity

• Adrenocortical dysfunction in obesity and the metabolic syndrome.
  (Krug AW, et al. Horm Metab Res. 2008 Aug;40(8):515-7. Epub 2008 Apr 30.)
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• Retinol-binding protein 4, visceral fat, and the metabolic syndrome: Effects of weight loss.
  (Tschoner A, et al. Obesity (Silver Spring). 2008 Aug 14. [Epub ahead of print])
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• Waist circumference cut-off points for the diagnosis of metabolic syndrome in Iranian adults.
  (Esteghamati A, et al. Diabetes Res Clin Pract. 2008 Aug 13. [Epub ahead of print])
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• Independent influence of insulin, catecholamines, and thyroid hormones on metabolic syndrome.
  (De Pergola G, et al. Obesity (Silver Spring). 2008 Aug 14. [Epub ahead of print])
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• Effect of bariatric surgery on the metabolic syndrome: a population-based, long-term controlled study.
  (Batsis JA, et al. Mayo Clin Proc. 2008 Aug;83(8):897-907.)
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Pediatrics

• Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity.
  (Caceres M, et al. BMC Pediatr. 2008 Aug 12;8:31.)
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• Metabolic syndrome affects fatty acid composition of plasma lipids in obese prepubertal children.
  (Gil-Campos M, et al. Lipids. 2008 Aug;43(8):723-32. Epub 2008 Jul 1.)
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• Large waist but low body mass index: the metabolic syndrome in Australian Aboriginal children.
  (Sellers EA, et al. J Pediatr. 2008 Aug;153(2):222-7. Epub 2008 Apr 3.)
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• Dietary intake and the metabolic syndrome in overweight Latino children.
  (Ventura EE, et al. J Am Diet Assoc. 2008 Aug;108(8):1355-9.)
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• The association of elevated alanine aminotransferase and the metabolic syndrome in an overweight and obese pediatric population of multi-ethnic origin.
  (van Vliet M, et al. Eur J Pediatr. 2008 Aug 12. [Epub ahead of print])
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• Longitudinal preventive-screening cutoffs for metabolic syndrome in adolescents.
  (Flouris AD, et al. Int J Obes (Lond). 2008 Aug 12. [Epub ahead of print])
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• Childhood predictors of the metabolic syndrome in adulthood. The Cardiovascular Risk in Young Finns Study.
  (Mattsson N, et al. Ann Med. 2008 Aug 26:1-11. [Epub ahead of print])
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• Relationship between body mass index and metabolic syndrome risk factors among US 8- to 14-year-olds, 1999 to 2002.
  (Messiah SE, et al. J Pediatr. 2008 Aug;153(2):215-21. Epub 2008 Apr 18.)
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• The prevalence of the metabolic syndrome in korean children and adolescents: Comparisons of the criteria of Cook et al., Cruz and Goran, and Ferranti et al.
  (Seo SJ, et al. Yonsei Med J. 2008 Aug 31;49(4):563-72.)
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Risk Factors

• Association of metabolic syndrome with cognitive function: The role of sex and age.
  (Laudisio A, et al. Clin Nutr. 2008 Aug 18. [Epub ahead of print])
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• Sociodemographic risk factors associated with metabolic syndrome in a Mediterranean population.
  (Buckland G, et al. Public Health Nutr. 2008 Aug 15:1-7. [Epub ahead of print])
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• Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis.
  (Grattagliano I, et al. J Nutr Biochem. 2008 Aug;19(8):491-504. Epub 2007 Sep 12.)
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• Hyperleptinemia as a robust risk factor of coronary artery disease and metabolic syndrome in type 2 diabetic patients.
  (Kim SK, et al. Endocr J. 2008 Aug 23. [Epub ahead of print])
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• Prevalence and clinical characteristics of metabolic syndrome for at-risk people in a rural community.
  (Oh EG, et al. Metab Syndr Relat Disord. 2008 Aug 30. [Epub ahead of print])
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• Variable contributions of fat content and distribution to metabolic syndrome risk factors.
  (Grundy SM, et al. Metab Syndr Relat Disord. 2008 Aug 30. [Epub ahead of print])
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• Prevalence of metabolic syndrome, obesity and diabetes type 2 in cryptogenic cirrhosis.
  (Tellez-Avila FI, et al. World J Gastroenterol. 2008 Aug 14;14(30):4771-5.)
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• Metabolic syndrome and three of its components as risk factors for recurrent ischaemic stroke presenting as large-vessel infarction.
  (Liou CW, et al. Eur J Neurol. 2008 Aug;15(8):802-9. Epub 2008 May 27.)
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• Metabolic syndrome is associated with impaired health-related quality of life: Lapinlahti 2005 study.
  (Miettola J, et al. Qual Life Res. 2008 Aug 31. [Epub ahead of print])
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• Association of the metabolic syndrome with severe periodontitis in a large U.S. population-based survey.
  (D'Aiuto F, et al. J Clin Endocrinol Metab. 2008 Aug 5. [Epub ahead of print])
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• Arterial stiffness, metabolic syndrome and inflammation amongst Asian ischaemic stroke patients.
  (De Silva DA, et al. Eur J Neurol. 2008 Aug;15(8):872-5. Epub 2008 Jun 28.)
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• Level, distribution and correlates of platelet-derived microparticles in healthy individuals with special reference to the metabolic syndrome.
  (Ueba T, et al. Thromb Haemost. 2008 Aug;100(2):280-5.)
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• High prevalence of metabolic syndrome after allogeneic hematopoietic cell transplantation.
  (Majhail NS, et al. Bone Marrow Transplant. 2008 Aug 25. [Epub ahead of print])
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