The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Adipose Tissue

• Increased epicardial adipose tissue volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis.
  (Wang CP, et al. Clin Endocrinol (Oxf). 2008 Sep 5. [Epub ahead of print])
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Biomarkers

• Plasma lecithin:cholesterol acyltransferase activity is elevated in metabolic syndrome and is an independent marker of increased carotid artery intima media thickness.
  (Dullaart RP, et al. J Clin Endocrinol Metab. 2008 Sep 9. [Epub ahead of print])
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• Exploring the usefulness of inflammation-sensitive biomarkers to reveal potential sex differences in relation to low-grade inflammation in individuals with the metabolic syndrome.
  (Rogowski O, et al. Metabolism. 2008 Sep;57(9):1221-6.)
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• Use of confirmatory factor analysis for the identification of new components of the metabolic syndrome: The role of plasminogen activator inhibitor-1 and Haemoglobin A1c.
  (Boronat M, et al. Nutr Metab Cardiovasc Dis. 2008 Sep 20. [Epub ahead of print])
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• Impact of the metabolic syndrome on the predictive values of new risk markers in the general population.
  (Olsen MH, et al. J Hum Hypertens. 2008 Sep;22(9):634-40. Epub 2008 Jun 5.)
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Cardiovascular Disease

• Molecular mechanisms of atherosclerosis in metabolic syndrome. Role of reduced IRS2-dependent signaling.
  (González-Navarro H, et al. Arterioscler Thromb Vasc Biol. 2008 Sep 18. [Epub ahead of print])
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Cognitive Function

• Metabolic syndrome and cognitive function in healthy middle-aged and older adults without diabetes.
  (Gatto NM, et al. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2008 Sep;15(5):627-41. Epub 2008 May 16.)
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Defining the Metabolic Syndrome

• Differences in traditional and emerging cardiovascular risk factors of subjects discordantly classified by metabolic syndrome definitions of the International Diabetes Federation and the National Cholesterol Education Program.
  (Boronat M, et al. Nutr Metab Cardiovasc Dis. 2008 Sep 24. [Epub ahead of print])
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• Metabolic syndrome according to different definitions in a rapidly developing country of the African region.
  (Kelliny C, et al. Cardiovasc Diabetol. 2008 Sep 18;7:27.)
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Diabetes

• Metabolic syndrome and incident diabetes: current state of the evidence.
  (Ford ES, et al. Diabetes Care. 2008 Sep;31(9):1898-904. Epub 2008 Jun 30.)
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• Type 2 diabetes mellitus and the metabolic syndrome following sleeve gastrectomy in severely obese subjects.
  (Vidal J, et al. Obes Surg. 2008 Sep;18(9):1077-82. Epub 2008 Jun 3.)
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Diet, Nutrition & Metabolism

• Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome.
  (Volek JS, et al. Prog Lipid Res. 2008 Sep;47(5):307-18. Epub 2008 Mar 15.)
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• n-3 Polyunsaturated fatty acids and trans fatty acids in patients with the metabolic syndrome: a case-control study in Korea.
  (Lee E, et al. Br J Nutr. 2008 Sep;100(3):609-14. Epub 2008 Feb 28.)
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• Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome.
  (Nigam A, et al. Nutr Metab Cardiovasc Dis. 2008 Sep 18. [Epub ahead of print])
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• s-ICAM-1 and s-VCAM-1 in healthy men are strongly associated with traits of the metabolic syndrome, becoming evident in the postprandial response to a lipid-rich meal.
  (Rubin D, et al. Lipids Health Dis. 2008 Sep 1;7:32.)
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• The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice.
  (Bose M, et al. J Nutr. 2008 Sep;138(9):1677-83.)
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Drug Therapy

• Prevalence and associations of the metabolic syndrome among patients prescribed clozapine.
  (Ahmed M, et al. Ir J Med Sci. 2008 Sep;177(3):205-10. Epub 2008 May 7.)
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• Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese zucker rats.
  (Rivera L, et al. Obesity (Silver Spring). 2008 Sep;16(9):2081-7. Epub 2008 Jun 12.)
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• Huang-Lian-Jie-Du-Tang inhibits myocardial remodeling in a rat model of metabolic syndrome.
  (Li X, et al. J Ethnopharmacol. 2008 Sep 26;119(2):259-265. Epub 2008 Jul 25.)
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• Felodipine attenuates vascular inflammation in a fructose-induced rat model of metabolic syndrome via the inhibition of NF-kappaB activation.
  (Tan HW, et al. Acta Pharmacol Sin. 2008 Sep;29(9):1051-9.)
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• Effects of losartan on serum total and high-molecular weight adiponectin concentrations in hypertensive patients with metabolic syndrome.
  (Uchida T, et al. Metabolism. 2008 Sep;57(9):1278-85.)
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• Effect of chronic aspirin administration on an experimental model of metabolic syndrome.
  (Renna NF, et al. Clin Exp Pharmacol Physiol. 2008 Sep 10. [Epub ahead of print])
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• Effect of irbesartan on erectile function in patients with hypertension and metabolic syndrome.
  (Baumhäkel M, et al. Int J Impot Res. 2008 Sep-Oct;20(5):493-500. Epub 2008 Jul 3.)
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• Peroxisome proliferator-activated receptor delta-agonist, GW501516, ameliorates insulin resistance, improves dyslipidaemia in monosodium L-glutamate metabolic syndrome mice.
  (Chen W, et al. Basic Clin Pharmacol Toxicol. 2008 Sep;103(3):240-6. Epub 2008 Jul 18.)
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Epidemiology

• Metabolic syndrome determinants in an urban population from Brazil: social class and gender-specific interaction.
  (Marquezine GF, et al. Int J Cardiol. 2008 Sep 26;129(2):259-65. Epub 2007 Nov 26.)
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• Prevalence and heritability of the metabolic syndrome and its individual components in a Dutch isolate: the Erasmus Rucphen Family study.
  (Henneman P, et al. J Med Genet. 2008 Sep;45(9):572-7. Epub 2008 Jun 11.)
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• Aggravation of albuminuria by metabolic syndrome in type 2 diabetic Asian subjects.
  (Lee IT, et al. Diabetes Res Clin Pract. 2008 Sep;81(3):345-50. Epub 2008 Jul 15.)
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• The metabolic syndrome identifies a heterogeneous group of metabolic component combinations in the Asia-Pacific region.
  (Lee CM, et al. Diabetes Res Clin Pract. 2008 Sep;81(3):377-80. Epub 2008 Jul 9.)
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• Low prevalence of metabolic syndrome and its components in rural Japan.
  (Morimoto A, et al. Tohoku J Exp Med. 2008 Sep;216(1):69-75.)
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• Impact of metabolic syndrome's components on the development of cardiovascular disease in a Jordanian cohort with metabolic syndrome.
  (Haddad FH, et al. Saudi Med J. 2008 Sep;29(9):1299-305.)
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• Metabolic syndrome: prevalence, associated factors, and C-reactive protein: the MADRIC (MADrid RIesgo Cardiovascular) Study.
  (Martínez MA, et al. Metabolism. 2008 Sep;57(9):1232-40.)
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• Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly Chinese.
  (Sun L, et al. J Clin Endocrinol Metab. 2008 Sep 16. [Epub ahead of print])
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• Hypertension is the most important component of metabolic syndrome in the association with ischemic heart disease in Taiwanese type 2 diabetic patients.
  (Tseng CH, et al. Circ J. 2008 Sep;72(9):1419-24.)
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• C-Reactive protein, insulin resistance, and metabolic syndrome in a population with a high burden of subclinical infection: Insights from the GOCADAN study.
  (Howard BV, et al. Diabetes Care. 2008 Sep 16. [Epub ahead of print])
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• Individual and area-based indicators of acculturation and the metabolic syndrome among low-income Mexican American women living in a border region.
  (Espinosa de Los Monteros K, et al. Am J Public Health. 2008 Sep 17. [Epub ahead of print])
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• Cross-sectional relationship between dietary carbohydrate, glycaemic index, glycaemic load and risk of the metabolic syndrome in a Korean population.
  (Kim K, et al. Br J Nutr. 2008 Sep;100(3):576-84. Epub 2008 Mar 10.)
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• The risk of metabolic syndrome according to the high-sensitivity C-reactive protein in apparently healthy Koreans.
  (Jung CH, et al. Int J Cardiol. 2008 Sep 26;129(2):266-71. Epub 2007 Nov 7.)
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Exercise & Physical Activity

• Enhanced concentrations of relevant markers of nitric oxide formation after exercise training in patients with metabolic syndrome.
  (Gomes VA, et al. Nitric Oxide. 2008 Sep 5. [Epub ahead of print])
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• Physical activity is negatively associated with the metabolic syndrome in the elderly.
  (Bianchi G, et al. QJM. 2008 Sep;101(9):713-21. Epub 2008 Jul 23.)
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Genetics

• Trends in metabolic syndrome and gene networks in human and rodent models.
  (Kraja AT, et al. Endocr Metab Immune Disord Drug Targets. 2008 Sep;8(3):198-207. Review.)
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• Association between BBS6/MKKS gene polymorphisms, obesity and metabolic syndrome in the Greek population.
  (Rouskas K, et al. Int J Obes (Lond). 2008 Sep 23. [Epub ahead of print])
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• The influence of polymorphism of -493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress.
  (Zák A, et al. J Nutr Biochem. 2008 Sep;19(9):634-41. Epub 2008 Feb 14.)
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• Relationship between vitamin D receptor BsmI and FokI polymorphisms and anthropometric and biochemical parameters describing metabolic syndrome.
  (Filus A, et al. Aging Male. 2008 Sep;11(3):134-9.)
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• The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides.
  (Dallongeville J, et al. BMC Med Genet. 2008 Sep 12;9:84.)
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• Prioritization of candidate disease genes for metabolic syndrome by computational analysis of its defining phenotypes.
  (Tiffin N, et al. Physiol Genomics. 2008 Sep 17;35(1):55-64. Epub 2008 Jul 8.)
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Hypertension

• Metabolic syndrome and multiple organ damage in essential hypertension.
  (Cuspidi C, et al. Blood Press. 2008 Sep 18:1-9. [Epub ahead of print])
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• Metabolic syndrome and biventricular hypertrophy in essential hypertension.
  (Cuspidi C, et al. J Hum Hypertens. 2008 Sep 18. [Epub ahead of print])
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• Metabolic syndrome: comparison of the two commonly used animal models.
  (Oron-Herman M, et al. Am J Hypertens. 2008 Sep;21(9):1018-22. Epub 2008 Jun 19.)
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• Plasma aldosterone and its relationships with left ventricular mass in essential hypertensive patients with the metabolic syndrome.
  (Mulè G, et al. Am J Hypertens. 2008 Sep;21(9):1055-61. Epub 2008 Jun 26.)
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• Diagnosis of insulin resistance in hypertensive patients by the metabolic syndrome: AHA vs. IDF definitions.
  (Hwu CM, et al. Int J Clin Pract. 2008 Sep;62(9):1441-6. Epub 2008 Jun 28.)
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Kidney Disease / Renal Function

• Metabolic syndrome and coronary artery calcification in renal transplant recipients.
  (Adeseun GA, et al. Transplantation. 2008 Sep 15;86(5):728-32.)
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• Initiation of glucose-based peritoneal dialysis is associated with increased prevalence of metabolic syndrome in non-diabetic patients with end-stage renal disease.
  (Jiang N, et al. Blood Purif. 2008 Sep 6;26(5):423-428. [Epub ahead of print])
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• Hypertensive women with the metabolic syndrome are at risk of renal insufficiency more than men in general population.
  (Korhonen P, et al. J Hum Hypertens. 2008 Sep 11. [Epub ahead of print])
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• Do thiazides worsen metabolic syndrome and renal disease? The pivotal roles for hyperuricemia and hypokalemia.
  (Reungjui S, et al. Curr Opin Nephrol Hypertens. 2008 Sep;17(5):470-6.)
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Metabolic Syndrome in Men

• Three definitions of metabolic syndrome applied to a sample of young obese men and their relation with plasma testosterone.
  (Goncharov NP, et al. Aging Male. 2008 Sep;11(3):118-22.)
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• Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups.
  (Kupelian V, et al. J Clin Endocrinol Metab. 2008 Sep;93(9):3403-10. Epub 2008 Jun 17.)
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• Is socioeconomic position related to the prevalence of metabolic syndrome? Influence of social class across the life-course in a population-based study of older men.
  (Ramsay SE, et al. Diabetes Care. 2008 Sep 22. [Epub ahead of print])
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• Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy.
  (Westerweel PE, et al. Eur Heart J. 2008 Sep 28. [Epub ahead of print])
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Metabolic Syndrome in Women

• Association between socioeconomic status and metabolic syndrome in women: testing the reserve capacity model.
  (Matthews KA, et al. Health Psychol. 2008 Sep;27(5):576-83.)
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• Comparison of metabolic syndrome variables among pregnant women with and without eclampsia.
  (Isezuo SA, et al. J Natl Med Assoc. 2008 Sep;100(9):1059-62.)
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• Women and the metabolic syndrome: an overview of its peculiarities.
  (Allende-Vigo MZ. P R Health Sci J. 2008 Sep;27(3):190-5.)
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• Menopause, the metabolic syndrome, and mind-body therapies.
  (Innes KE, et al. Menopause. 2008 Sep-Oct;15(5):1005-13.)
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Non-Alcoholic Fatty Liver Disease

• The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantation.
  (Hanouneh IA, et al. Liver Transpl. 2008 Sep;14(9):1287-93.)
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• Metabolic syndrome as a risk factor for nonalcoholic fatty liver disease.
  (Tsai CH, et al. South Med J. 2008 Sep;101(9):900-5.)
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• Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis.
  (DeLeve LD, et al. Am J Pathol. 2008 Oct;173(4):993-1001. Epub 2008 Sep 4.)
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Obesity

• Central obesity as a precursor to the metabolic syndrome in the AusDiab study and mauritius.
  (Cameron AJ, et al. Obesity (Silver Spring). 2008 Sep 25. [Epub ahead of print])
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• Adiponectin multimers and metabolic syndrome traits: Relative adiponectin resistance in African Americans.
  (Lara-Castro C, et al. Obesity (Silver Spring). 2008 Sep 25. [Epub ahead of print])
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Pediatrics

• Prevalence of metabolic syndrome and related characteristics in obese adolescents with and without polycystic ovary syndrome.
  (Rossi B, et al. J Clin Endocrinol Metab. 2008 Sep 23. [Epub ahead of print])
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• Acylation stimulating protein but not complement C3 associates with metabolic syndrome components in Chinese children and adolescents.
  (Fouejeu Wamba P, et al. Eur J Endocrinol. 2008 Sep 19. [Epub ahead of print])
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• Cardiac markers of pre-clinical disease in adolescents with the metabolic syndrome: the strong heart study.
  (Chinali M, et al. J Am Coll Cardiol. 2008 Sep 9;52(11):932-8.)
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• Identifying adolescent metabolic syndrome using body mass index and waist circumference.
  (Camhi SM, et al. Prev Chronic Dis. 2008 Oct;5(4):A115. Epub 2008 Sep 15.)
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• Sleep-disordered breathing in children with metabolic syndrome: the role of leptin and sympathetic nervous system activity and the effect of continuous positive airway pressure.
  (Nakra N, et al. Pediatrics. 2008 Sep;122(3):e634-42.)
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• Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight-loss in obese children and adolescents.
  (Deram S, et al. J Clin Endocrinol Metab. 2008 Sep 23. [Epub ahead of print])
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• Factors associated with the metabolic syndrome in a national sample of youths: CASPIAN Study.
  (Kelishadi R, et al. Nutr Metab Cardiovasc Dis. 2008 Sep;18(7):461-70. Epub 2007 Nov 1.)
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• Adipokines and the prediction of the accumulation of cardiovascular risk factors or the presence of metabolic syndrome in elementary school children.
  (Yoshinaga M, et al. Circ J. 2008 Sep 24. [Epub ahead of print])
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• Is sleep-disordered breathing an additional risk factor for the metabolic syndrome in obese children and adolescents?
  (Verhulst SL, et al. Int J Obes (Lond). 2008 Sep 9. [Epub ahead of print])
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Psychological Disorders

• Metabolic syndrome and schizophrenia from integrative medicine perspective.
  (Maslov B, et al. Psychiatr Danub. 2008 Sep;20(3):384-9.)
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• A comparison of schizophrenia outpatients treated with antipsychotics with and without metabolic syndrome: Findings from the CLAMORS study.
  (Arango C, et al. Schizophr Res. 2008 Sep;104(1-3):1-12. Epub 2008 Jul 7.)
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• Metabolic syndrome and depression in war veterans with post-traumatic stress disorder.
  (Jakovljevic' M, et al. Psychiatr Danub. 2008 Sep;20(3):406-10.)
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• Relative risk of diabetes, dyslipidaemia, hypertension and the metabolic syndrome in people with severe mental illnesses. Systematic review and metaanalysis.
  (Osborn DP, et al. BMC Psychiatry. 2008 Sep 25;8(1):84. [Epub ahead of print])
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Risk Factors

• Risk for metabolic syndrome predisposes to alterations in the thalamic metabolism.
  (Heikkilä O, et al. Metab Brain Dis. 2008 Sep;23(3):315-24. Epub 2008 Jul 22.)
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• Relationship between lower urinary tract symptoms and metabolic syndrome in a community-based elderly population.
  (Park HK, et al. Urology. 2008 Sep;72(3):556-60. Epub 2008 Jul 2.)
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• IGF-I/IGFBP- 3 ratio: a mechanistic insight into the metabolic syndrome.
  (Sierra-Johnson J, et al. Clin Sci (Lond). 2008 Sep 24. [Epub ahead of print])
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• Metabolic syndrome is associated with erosive esophagitis.
  (Park JH, et al. World J Gastroenterol. 2008 Sep 21;14(35):5442-7.)
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• The association of the metabolic syndrome with T-wave axis deviation in NHANES III.
  (Faramawi MF, et al. Ann Epidemiol. 2008 Sep;18(9):702-7.)
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• Serum nitric oxide metabolites in subjects with metabolic syndrome.
  (Zahedi Asl S, et al. Clin Biochem. 2008 Sep 3. [Epub ahead of print])
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• The clinical implications of the emerging link between hypogonadism & metabolic syndrome.
  (Guay AT. J Androl. 2008 Sep 4. [Epub ahead of print])
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• Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome.
  (Agouni A, et al. Am J Pathol. 2008 Oct;173(4):1210-9. Epub 2008 Sep 4.)
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• Respiratory sleep disturbances in patients undergoing gastric bypass surgery and their relation to metabolic syndrome.
  (Salord N, et al. Obes Surg. 2008 Sep 16. [Epub ahead of print])
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• Individual and neighborhood socioeconomic status characteristics and prevalence of metabolic syndrome: The Atherosclerosis Risk in Communities (ARIC) Study.
  (Chichlowska KL, et al. Psychosom Med. 2008 Sep 16. [Epub ahead of print])
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• Small, dense low-density lipoproteins are predictors of cardio- and cerebro-vascular events in subjects with the metabolic syndrome.
  (Rizzo M, et al. Clin Endocrinol (Oxf). 2008 Sep 2. [Epub ahead of print])
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• Metabolic syndrome predicts 10-year mortality in non-diabetic patients following coronary artery bypass surgery.
  (Kajimoto K, et al. Circ J. 2008 Sep;72(9):1481-6.)
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• The metabolic syndrome and mortality in an ethnically diverse heart failure population.
  (Hassan SA, et al. J Card Fail. 2008 Sep;14(7):590-5. Epub 2008 May 27.)
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• Relation of the number of metabolic syndrome risk factors with all-cause and cardiovascular mortality.
  (Ho JS, et al. Am J Cardiol. 2008 Sep 15;102(6):689-92. Epub 2008 Jun 26.)
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• Differential impact of metabolic syndrome on arterial stiffness and wave reflections: Focus on distinct definitions.
  (Vyssoulis GP, et al. Int J Cardiol. 2008 Sep 18. [Epub ahead of print])
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• Relationship between brachial-ankle pulse wave velocity and cognitive function in an elderly community-dwelling population with metabolic syndrome.
  (Kim YS, et al. Arch Gerontol Geriatr. 2008 Sep 9. [Epub ahead of print])
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• Occupation-related differences in the prevalence of metabolic syndrome.
  (Sánchez-Chaparro MA, et al. Diabetes Care. 2008 Sep;31(9):1884-5. Epub 2008 Jun 20.)
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• Association of brominated flame retardants with diabetes and metabolic syndrome in the U.S. population, 2003-2004.
  (Lim JS, et al. Diabetes Care. 2008 Sep;31(9):1802-7. Epub 2008 Jun 16.)
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• Glycaemic variability and inflammation in subjects with metabolic syndrome.
  (Buscemi S, et al. Acta Diabetol. 2008 Sep 26. [Epub ahead of print])
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• The "metabolic syndrome" is less useful than random plasma glucose to screen for glucose intolerance.
  (El Bassuoni EA, et al. Prim Care Diabetes. 2008 Sep;2(3):147-53. Epub 2008 Jun 11.)
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