The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Adipose Tissue

• Fatty acid binding proteins in adipose tissue: A promising link between metabolic syndrome and atherosclerosis?
  (Krušinová E, et al. Diabetes Res Clin Pract. 2008 Oct 30. [Epub ahead of print])
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Apo / Lipoproteins

• How to reach LDL targets quickly in patients with diabetes or metabolic syndrome.
  (Leiter LA, et al. J Fam Pract. 2008 Oct;57(10):661-8.)
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• Metabolic syndrome is strongly associated with chronic subclinical inflammation in patients achieving optimal low-density lipoprotein-cholesterol levels in secondary prevention of cardiovascular disease.
  (Matsuo Y, et al. Circ J. 2008 Oct 21. [Epub ahead of print])
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• Plasma apolipoprotein CI and CIII levels are associated with increased plasma triglyceride levels and decreased fat mass in men with the metabolic syndrome.
  (van der Ham RL, et al. Diabetes Care. 2008 Oct 3. [Epub ahead of print])
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• Lipoprotein particle distribution and size, insulin resistance, and metabolic syndrome in Alaska Eskimos: the GOCADAN study.
  (Rivellese AA, et al. Atherosclerosis. 2008 Oct;200(2):350-8. Epub 2008 Apr 18.)
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• Non-high-density lipoprotein cholesterol in patients with metabolic syndrome.
  (Huang J, et al. J Investig Med. 2008 Oct;56(7):931-6.)
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Biomarkers

• Effect of weight loss on markers of triglyceride-rich lipoprotein metabolism in the metabolic syndrome.
  (Chan DC, et al. Eur J Clin Invest. 2008 Oct;38(10):743-51.)
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• The therapeutic modulation of atherogenic dyslipidemia and inflammatory markers in the metabolic syndrome: what is the clinical relevance?
  (Rizzo M, et al. Acta Diabetol. 2008 Oct 17. [Epub ahead of print])
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Cancer

• Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat.
  (La Merrill M, et al. Am J Physiol Endocrinol Metab. 2008 Oct 7. [Epub ahead of print])
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Cardiovascular Disease

• Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome.
  (Agouni A, et al. Am J Pathol. 2008 Oct;173(4):1210-9. Epub 2008 Sep 4.)
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• The effects of pre-disease risk factors within metabolic syndrome on all-cause and cardiovascular disease mortality.
  (Tsai SP, et al. Diabetes Res Clin Pract. 2008 Oct;82(1):148-56. Epub 2008 Aug 30.)
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• Beyond cholesterol lowering: pleiotropic effects of bile acid binding resins against cardiovascular disease risk factors in patients with metabolic syndrome.
  (Yamaoka-Tojo M, et al. Curr Vasc Pharmacol. 2008 Oct;6(4):271-81.)
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• Myocardial ischemic-reperfusion injury in a rat model of metabolic syndrome.
  (Mozaffari MS, et al. Obesity (Silver Spring). 2008 Oct;16(10):2253-8. Epub 2008 Jul 24.)
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• Metabolic syndrome in patients with ischemic heart disease.
  (Yasmin S, et al. J Coll Physicians Surg Pak. 2008 Oct;18(10):605-7.)
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Cognitive Function

• Association of metabolic syndrome with cognitive function: the role of sex and age.
  (Laudisio A, et al. Clin Nutr. 2008 Oct;27(5):747-54. Epub 2008 Aug 19.)
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• Cognitive functioning in elderly persons with type 2 diabetes and metabolic syndrome: the Hoorn study.
  (van den Berg E, et al. Dement Geriatr Cogn Disord. 2008;26(3):261-9. Epub 2008 Oct 8.)
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• Metabolic syndrome and risk for incident Alzheimer's disease or vascular demential: The THREE-CITY STUDY.
  (Raffaitin C, et al. Diabetes Care. 2008 Oct 22. [Epub ahead of print])
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• Idiopathic neuropathy patients are at high risk for metabolic syndrome.
  (Smith AG, et al. J Neurol Sci. 2008 Oct 15;273(1-2):25-8. Epub 2008 Jul 7.)
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Defining the Metabolic Syndrome

• The metabolic syndrome.
  (Cornier MA, et al. Endocr Rev. 2008 Oct 29. [Epub ahead of print])
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Diabetes

• Heightened efficacy of nitric oxide-based therapies in type II diabetes mellitus and metabolic syndrome.
  (Ahanchi SS, et al. Am J
  Physiol Heart Circ Physiol. 2008 Oct 17. [Epub ahead of print])
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• Adult metabolic syndrome and impaired glucose tolerance are associated with different patterns of body mass index gain during infancy; Data from the New Delhi birth cohort.
  (Fall CH, et al. Diabetes Care. 2008 Oct 3. [Epub ahead of print])
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• Metabolic Syndrome and autoimmune diabetes: ACTION LADA 3.
  (Hawa MI, et al. Diabetes Care. 2008 Oct 22. [Epub ahead of print])
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• Association of C-reactive protein with reduced forced vital capacity in a nonsmoking U.S. population with metabolic syndrome and diabetes.
  (Lee HM, et al. Diabetes Care. 2008 Oct;31(10):2000-2. Epub 2008 Jun 30.)
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Diet, Nutrition & Metabolism

• Body iron stores in relation to the metabolic syndrome, glycemic control and complications in female patients with type 2 diabetes.
  (Mojiminiyi OA, et al. Nutr Metab Cardiovasc Dis. 2008 Oct;18(8):559-66. Epub 2007 Dec 11.)
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• Opposite effects of metabolic syndrome and calorie restriction on thrombotic disease: Head and tail of same coin-resveratrol's role.
  (Cacciapuoti F. Metab Syndr Relat Disord. 2008 Oct 18. [Epub ahead of print])
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Drug Therapy

• Resistance to aspirin and thienopyridines in diabetes mellitus and metabolic syndrome.
  (Anfossi G, et al. Curr Vasc Pharmacol. 2008 Oct;6(4):313-28.)
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• Medicinal agents in the metabolic syndrome.
  (Baños G, et al. Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):237-52.)
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• Metabolic syndrome patient compliance with drug treatment.
  (Lopes N, et al. Clinics. 2008 Oct;63(5):573-80.)
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• Atorvastatin and fenofibrate have comparable effects on VLDL-apolipoprotein C-III kinetics in men with the metabolic syndrome.
  (Chan DC, et al. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1831-7. Epub 2008 Jun 19.)
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Epidemiology

• Differing definition-based prevalence of metabolic syndrome in the women of Oman family study: a function of multiparity.
  (Al-barwani SA, et al. Metab Syndr Relat Disord. 2008 Fall;6(3):197-202.)
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• Prevalence of metabolic syndrome in Pakistan.
  (Basit A, et al. Metab Syndr Relat Disord. 2008 Fall;6(3):171-5.)
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• The prevalence of metabolic syndrome in an employed population and the impact on health and productivity.
  (Burton WN, et al. J Occup Environ Med. 2008 Oct;50(10):1139-1148.)
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• Prevalence of metabolic syndrome in Chinese renal transplant recipients.
  (Cheung CY, et al. Hong Kong Med J. 2008 Oct;14(5):379-84.)
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• Serum erythrocyte sedimentation rate is higher among ethnic South Asian compared to ethnic Chinese ischemic stroke patients. Is this attributable to metabolic syndrome or central obesity?
  (De Silva DA, et al. J Neurol Sci. 2008 Oct 17. [Epub ahead of print])
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• Waist circumference cut-off points for the diagnosis of metabolic syndrome in Iranian adults.
  (Esteghamati A, et al. Diabetes Res Clin Pract. 2008 Oct;82(1):104-7. Epub 2008 Aug 15.)
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• Prevalence of metabolic syndrome in urban pakistan (Karachi): Comparison of newly proposed international diabetes federation and modified Adult Treatment Panel III criteria.
  (Hydrie MZ, et al. Metab Syndr Relat Disord. 2008 Oct 18. [Epub ahead of print])
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• Metabolic syndrome in carbon disulfide-poisoned subjects in Korea: does chemical poisoning induce metabolic syndrome?
  (Jhun HJ, et al. Int Arch Occup Environ Health. 2008 Oct 25. [Epub ahead of print])
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• Obesity and the metabolic syndrome in the elderly--a mini-review.
  (Lechleitner M. Gerontology. 2008;54(5):253-9. Epub 2008 Oct 8.)
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• A more simplified Finnish diabetes risk Score for opportunistic screening of undiagnosed type 2 diabetes in a German population with a family history of the metabolic syndrome.
  (Li J, et al. Horm Metab Res. 2008 Oct 29. [Epub ahead of print])
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• Confirming a biological pathway in the metabolic syndrome-insight from the NHANES 1999-2002.
  (Lin LY, et al. Obesity (Silver Spring). 2008 Oct 9. [Epub ahead of print])
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• Association between metabolic syndrome and nephrolithiasis in an inpatient population in southern Italy: role of gender, hypertension and abdominal obesity.
  (Rendina D, et al. Nephrol Dial Transplant. 2008 Oct 3. [Epub ahead of print])
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• Metabolic syndrome and all-cause and cardiovascular mortality in an Italian elderly population: The Progetto Veneto Anziani (Pro.V.A.) STUDY.
  (Zambon S, et al. Diabetes Care. 2008 Oct 17. [Epub ahead of print])
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• Frequency and determinants of the metabolic syndrome in apparently healthy adult Nigerians.
  (Wahab KW, et al. Trop Doct. 2008 Oct;38(4):224-6.)
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• The prevalence of the metabolic syndrome among the multiethnic population of the United Arab Emirates: a report of a national survey.
  (Malik M, et al. Metab Syndr Relat Disord. 2008 Fall;6(3):177-86.)
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• Metabolic syndrome predicts new onset of chronic kidney disease in 5829 patients with type 2 diabetes - A 5-year prospective analysis of the Hong Kong diabetes registry.
  (Luk AO, et al. Diabetes Care. 2008 Oct 3. [Epub ahead of print])
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• Time-dependent association between metabolic syndrome and risk of CKD in Korean men without hypertension or diabetes.
  (Ryu S, et al. Am J Kidney Dis. 2008 Oct 4. [Epub ahead of print])
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• Could quality of life impact the prevalence of metabolic syndrome? Results from a population-based study of Swedish women: the Women's Health in the Lund Area Study.
  (Qader SS, et al. Metab Syndr Relat Disord. 2008 Fall;6(3):203-7.)
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Exercise & Physical Activity

• Restorative yoga in adults with metabolic syndrome: a randomized, controlled pilot trial.
  (Cohen BE, et al. Metab Syndr Relat Disord. 2008 Fall;6(3):223-9.)
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• A preliminary study of the effects of Tai Chi and Qigong medical exercise on indicators of metabolic syndrome, glycaemic control, health related quality of life, and psychological health in adults with elevated blood glucose.
  (Liu X, et al. Br J Sports Med. 2008 Oct 16. [Epub ahead of print])
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• Year-long physical activity and metabolic syndrome in older Japanese adults: cross-sectional data from the nakanojo study.
  (Park S, et al. J Gerontol A Biol Sci Med Sci. 2008 Oct;63(10):1119-23.)
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Genetics

• Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population.
  (Carter KW, et al. Hum Genet. 2008 Oct;124(3):199-206. Epub 2008 Aug 21.)
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• The - 11391 G/A polymorphism of the adiponectin gene promoter is associated with metabolic syndrome traits and the outcome of an energy-restricted diet in obese subjects.
  (Goyenechea E, et al. Horm Metab Res. 2008 Oct 23. [Epub ahead of print])
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• Alterations in the high density lipoprotein phenotype and HDL-associated enzymes in subjects with metabolic syndrome.
  (Lagos KG, et al. Lipids. 2008 Oct 28. [Epub ahead of print])
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• CETP TaqIB polymorphism in Turkish adults: association with dyslipidemia and metabolic syndrome.
  (Ozsait B, et al. Anadolu Kardiyol Derg. 2008 Oct;8(5):324-30.)
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• Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease.
  (Powell BL, et al. Hum Genet. 2008 Oct;124(3):263-70. Epub 2008 Aug 30.)
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• Genetic variants associated with insulin resistance and metabolic syndrome in young Asian Indians with myocardial infarction.
  (Ranjith N, et al. Metab Syndr Relat Disord. 2008 Fall;6(3):209-14.)
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• Association of C34T AMPD1 gene polymorphism with features of metabolic syndrome in patients with coronary artery disease or heart failure.
  (Safranow K, et al. Scand J Clin Lab Invest. 2008 Oct 14:1-11. [Epub ahead of print])
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• Effect of the rs997509 polymorphism on the association between ENPP1, metabolic syndrome, and impaired glucose tolerance in childhood obesity.
  (Santoro N, et al. J Clin Endocrinol Metab. 2008 Oct 21. [Epub ahead of print])
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• The search for putative unifying genetic factors for components of the metabolic syndrome.
  (Sjögren M, et al. Diabetologia. 2008 Oct 14. [Epub ahead of print])
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Hypertension

• Increased prevalence of metabolic syndrome in uncontrolled hypertension across Europe: the Global Cardiometabolic Risk Profile in patients with hypertension disease survey.
  (Kjeldsen SE, et al. J Hypertens. 2008 Oct;26(10):2064-70.)
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• Blood pressure and fasting plasma glucose rather than metabolic syndrome predict coronary artery calcium progression: The Rancho Bernardo Study.
  (Kramer CK, et al. Diabetes Care. 2008 Oct 13. [Epub ahead of print])
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• The metabolic syndrome in hypertension: European society of hypertension position statement.
  (Redon J, et al. J Hypertens. 2008 Oct;26(10):1891-900.)
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• Nocturnal blood pressure fall and metabolic syndrome score in patients with white coat hypertension.
  (Vyssoulis G, et al. Blood Press Monit. 2008 Oct;13(5):251-6.)
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Metabolic Syndrome in Men

• Relationship between serum prostate-specific antigen levels and components of metabolic syndrome in healthy men.
  (Han JH, et al. Urology. 2008 Oct;72(4):749-54; discussion 754-5. Epub 2008 Aug 13.)
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Metabolic Syndrome in Women

• Effects of androgens on insulin action in women: is androgen excess a component of female metabolic syndrome?
  (Corbould A. Diabetes Metab Res Rev. 2008 Oct;24(7):520-32.)
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• Cardiometabolic risk in polycystic ovary syndrome: a comparison of different approaches to defining the metabolic syndrome.
  (Cussons AJ, et al. Hum Reprod. 2008 Oct;23(10):2352-8. Epub 2008 Jul 16.)
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• Metabolic syndrome components in relation to risk of cataract extraction: a prospective cohort study of women.
  (Lindblad BE, et al. Ophthalmology. 2008 Oct;115(10):1687-92. Epub 2008 Jun 5.)
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• Independent and opposite associations of hip and waist circumference with metabolic syndrome components and with inflammatory and atherothrombotic risk factors in overweight and obese women.
  (Rocha PM, et al. Metabolism. 2008 Oct;57(10):1315-22.)
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• Metabolic syndrome affects cardiovascular risk profile and response to treatment in hypertensive postmenopausal women.
  (Rossi R, et al. Hypertension. 2008 Nov;52(5):865-72. Epub 2008 Oct 13.)
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• Relative androgen excess during the menopausal transition predicts incident metabolic syndrome in midlife women: Study of Women's Health Across the Nation.
  (Torréns JI, et al. Menopause. 2008 Oct 27. [Epub ahead of print])
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Non-Alcoholic Fatty Liver Disease

• Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis.
  (DeLeve LD, et al. Am J Pathol. 2008 Oct;173(4):993-1001. Epub 2008 Sep 4.)
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• Impact of visceral fat on the metabolic syndrome and nonalcoholic Fatty liver disease.
  (Jeong SK, et al. J Korean Med Sci. 2008 Oct;23(5):789-95.)
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• Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome.
  (Kim CH, et al. Cleve Clin J Med. 2008 Oct;75(10):721-8.)
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Obesity

• Metabolic syndrome after laparoscopic bariatric surgery.
  (Nugent C, et al. Obes Surg. 2008 Oct;18(10):1278-86. Epub 2008 Apr 9.)
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• Bariatric surgery outcomes in morbidly obese with the metabolic syndrome at US academic centers.
  (Varela JE, et al. Obes Surg. 2008 Oct;18(10):1273-7. Epub 2008 Apr 22.)
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Pediatrics

• Cardiovascular fitness, insulin resistance and metabolic syndrome in severely obese prepubertal Italian children.
  (Brufani C, et al. Horm Res. 2008 Oct 27;70(6):349-356. [Epub ahead of print])
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• Identifying adolescent metabolic syndrome using body mass index and waist circumference.
  (Camhi SM, et al. Prev Chronic Dis. 2008 Oct;5(4):A115. Epub 2008 Sep 15.)
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• Prevalence and risk factors of metabolic syndrome in Brazilian and Italian obese adolescents: a comparison study.
  (Caranti DA, et al. Int J Clin Pract. 2008 Oct;62(10):1526-32.)
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• Longitudinal preventive-screening cutoffs for metabolic syndrome in adolescents.
  (Flouris AD, et al. Int J Obes (Lond). 2008 Oct;32(10):1506-12. Epub 2008 Aug 12.)
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• Metabolic syndrome by the new IDF criteria in Hong Kong Chinese adolescents and its prediction by using body mass index.
  (Kong AP, et al. Acta Paediatr. 2008 Oct 6. [Epub ahead of print])
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• Changes in risk variables of metabolic syndrome since childhood in pre-diabetic and type 2 diabetic subjects: the Bogalusa Heart Study.
  (Nguyen QM, et al. Diabetes Care. 2008 Oct;31(10):2044-9. Epub 2008 Jul 15.)
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• Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children.
  (Pacifico L, et al. Eur J Endocrinol. 2008 Oct 24. [Epub ahead of print])
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• Prevalence and risk factors of metabolic syndrome in obese children and adolescents: the role of the severity of obesity.
  (Sen Y, et al. Eur J Pediatr. 2008 Oct;167(10):1183-9. Epub 2008 Jan 17.)
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• Prevalence of the metabolic syndrome among a racially/ethnically diverse group of U.S. eighth-grade adolescents and associations with fasting insulin and homeostasis model assessment of insulin resistance levels.
  (Studies to Treat or Prevent Pediatric Type 2 Diabetes Prevention Study Group. Diabetes Care. 2008 Oct;31(10):2020-5. Epub 2008 Jun 30.)
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• Metabolic syndrome in children and adolescents--risk for sleep-disordered breathing and obstructive sleep-apnoea syndrome?
  (Körner A, et al. Arch Physiol Biochem. 2008 Oct;114(4):237-43.)
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Psychological Disorders

• Depression: an important co morbidity with metabolic syndrome in a general population.
  (Dunbar JA, et al. Diabetes Care. 2008 Oct 3. [Epub ahead of print])
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Risk Factors

• The quest for the optimal assessment of global cardiovascular risk: Are traditional risk factors and metabolic syndrome partners in crime?
  (Arsenault BJ, et al. Cardiology. 2008 Oct 30;113(1):35-49. [Epub ahead of print])
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• Metabolic syndrome and visceral obesity as risk factors for reflux oesophagitis: a cross-sectional case-control study of 7078 Koreans undergoing health check-ups.
  (Chung SJ, et al. Gut. 2008 Oct;57(10):1360-5. Epub 2008 Apr 25.)
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• Association of the metabolic syndrome with severe periodontitis in a large U.S. population-based survey.
  (D'Aiuto F, et al. J Clin Endocrinol Metab. 2008 Oct;93(10):3989-94. Epub 2008 Aug 5.)
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• Patterns of alcohol consumption and the metabolic syndrome.
  (Fan AZ, et al. J Clin Endocrinol Metab. 2008 Oct;93(10):3833-8. Epub 2008 Jul 15.)
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• NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?
  (Guichard C, et al. Biochem Soc Trans. 2008 Oct;36(Pt 5):920-9.)
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• Risk of metabolic syndrome, cardiovascular disease, and diabetes in androgen deprivation therapy.
  (Leahy Y. Clin J Oncol Nurs. 2008 Oct;12(5):771-6.)
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• Metabolic syndrome is associated with impaired health-related quality of life: Lapinlahti 2005 study.
  (Miettola J, et al. Qual Life Res. 2008 Oct;17(8):1055-62. Epub 2008 Aug 31.)
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• A prospective study of determinants of the metabolic syndrome in adults.
  (Mirmiran P, et al. Nutr Metab Cardiovasc Dis. 2008 Oct;18(8):567-73. Epub 2008 Feb 20.)
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• A possible association between suspected restrictive pattern as assessed by ordinary pulmonary function test and the metabolic syndrome.
  (Nakajima K, et al. Chest. 2008 Oct;134(4):712-8. Epub 2008 Jul 14.)
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• Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes.
  (Ohnishi T, et al. J Periodontal Res. 2008 Oct 7. [Epub ahead of print])
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• Metabolic syndrome clusters and the risk of incident stroke. The Atherosclerosis Risk in Communities (ARIC) Study.
  (Rodriguez-Colon SM, et al. Stroke. 2008 Oct 16. [Epub ahead of print])
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• Acute mountain sickness in a subject with metabolic syndrome at high altitude.
  (Strapazzon G, et al. High Alt Med Biol. 2008 Fall;9(3):245-8.)
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• Metabolic syndrome increases the risk of liver cirrhosis in chronic Hepatitis B.
  (Wong GL, et al. Gut. 2008 Oct 2. [Epub ahead of print])
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Sleep Disorders

• Effects of continuous positive airway pressure on cardiovascular risk profile in patients with severe obstructive sleep apnea and metabolic syndrome.
  (Dorkova Z, et al. Chest. 2008 Oct;134(4):686-92. Epub 2008 Jul 14.)
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