The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Adipose Tissue

• Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome.
  (Vural B, et al. Cardiovasc Pathol. 2008 Nov-Dec;17(6):392-8. Epub 2008 Apr 15.)
  View Abstract

> Back to Top

Apo / Lipoproteins

• Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study.
  (Tsimikas S, et al. Eur Heart J. 2008 Nov 19. [Epub ahead of print])
  View Abstract
• Relationship of serum resistin level to traits of metabolic syndrome and serum paraoxonase 1 activity in a population with a broad range of body mass index.
  (Bajnok L, et al. Exp Clin Endocrinol Diabetes. 2008 Nov;116(10):592-9. Epub 2008 May 9.)
  View Abstract

> Back to Top

Biomarkers

• Metabolic syndrome in postmenopausal women: the influence of oral or transdermal estradiol on inflammation and coagulation markers.
  (Chu MC, et al. Am J Obstet Gynecol. 2008 Nov;199(5):526.e1-7. Epub 2008 Jun 3.)
  View Abstract
• Insulin resistance, serum adiponectin, and proinflammatory markers in young subjects with the metabolic syndrome.
  (Kowalska I, et al. Metabolism. 2008 Nov;57(11):1539-44.)
  View Abstract
• Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults.
  (Puchau B, et al. Eur J Clin Nutr. 2008 Nov 5. [Epub ahead of print])
  View Abstract
• Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese.
  (Qi Q, et al. Eur J Endocrinol. 2008 Nov;159(5):585-93. Epub 2008 Aug 27.)
  View Abstract
• The association between circulating inflammatory markers and metabolic syndrome in korean rural adults.
  (Ryu SY, et al. J Prev Med Public Health. 2008 Nov;41(6):413-8.)
  View Abstract

> Back to Top

Cancer

• Metabolic syndrome after risk-reducing salpingo-oophorectomy in women at high risk for hereditary breast ovarian cancer: A controlled observational study.
  (Michelsen TM, et al. Eur J Cancer. 2008 Nov 13. [Epub ahead of print])
  View Abstract

> Back to Top

Cardiovascular Disease

• The metabolic syndrome increased risk of cardiovascular events in Chinese-A community based study.
  (Wang C, et al. Int J Cardiol. 2008 Nov 27. [Epub ahead of print])
  View Abstract
• A twin study of metabolic syndrome and autonomic tone.
  (Gehi AK, et al. J Cardiovasc Electrophysiol. 2008 Nov 19. [Epub ahead of print])
  View Abstract
• Cardioprotection by postconditioning is lost in WOKW rats with metabolic syndrome: role of glycogen synthase kinase 3beta.
  (Wagner C, et al. J Cardiovasc Pharmacol. 2008 Nov;52(5):430-7.)
  View Abstract

> Back to Top

Defining the Metabolic Syndrome

• Comparison of diagnostic criteria of the metabolic syndrome in 3 ethnic groups of Canada.
  (Chateau-Degat ML, et al. Metabolism. 2008 Nov;57(11):1526-32.)
  View Abstract

> Back to Top

Diabetes

• The impact of metabolic syndrome on insulin sensitivity, glucose sensitivity, and acute insulin response after glucose load in early-onset type 2 diabetes mellitus: Taiwan Early-Onset Type 2 Diabetes Cohort Study.
  (Hsieh CH, et al. Metabolism. 2008 Nov;57(11):1615-21.)
  View Abstract
• The metabolic syndrome, diabetes and lung dysfunction.
  (Tiengo A, et al. Diabetes Metab. 2008 Nov;34(5):447-54. Epub 2008 Sep 30.)
  View Abstract

> Back to Top

Diet, Nutrition & Metabolism

• Dietary fiber in the prevention and treatment of metabolic syndrome: a review.
  (Aleixandre A, et al. Crit Rev Food Sci Nutr. 2008 Nov;48(10):905-12.)
  View Abstract
• A culturally appropriate diet and lifestyle intervention can successfully treat the components of metabolic syndrome in female Pakistani immigrants residing in Melbourne, Australia.
  (Kousar R, et al. Metabolism. 2008 Nov;57(11):1502-8.)
  View Abstract
• Enhancement of a modified Mediterranean-style, low glycemic load diet with specific phytochemicals improves cardiometabolic risk factors in subjects with metabolic syndrome and hypercholesterolemia in a randomized trial.
  (Lerman RH, et al. Nutr Metab (Lond). 2008 Nov 4;5:29.)
  View Abstract
• Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols.
  (de Moura RF, et al. Br J Nutr. 2008 Nov 14:1-7. [Epub ahead of print])
  View Abstract
• Red clover extract: a putative source for simultaneous treatment of menopausal disorders and the metabolic syndrome.
  (Mueller M, et al. Menopause. 2008 Nov-Dec;15(6):1120-31.)
  View Abstract
• Increased plasma activity of metalloproteinase 2 in women with metabolic syndrome.
  (Miksztowicz V, et al. Metabolism. 2008 Nov;57(11):1493-6.)
  View Abstract
• Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss.
  (Lundgren JD, et al. Int J Obes (Lond). 2008 Nov 18. [Epub ahead of print])
  View Abstract
• Session 2: Personalised nutrition. Transcriptomic signatures that have identified key features of metabolic syndrome.
  (Morine MJ, et al. Proc Nutr Soc. 2008 Nov;67(4):395-403.)
  View Abstract

> Back to Top

Drug Therapy

• Effect of fenofibrate on adiponectin and inflammatory biomarkers in metabolic syndrome patients.
  (Rosenson RS. Obesity (Silver Spring). 2008 Nov 20. [Epub ahead of print])
  View Abstract
• The effects of fenofibrate treatment on cardiovascular disease risk in 9795 people with type 2 diabetes and various components of the metabolic syndrome: the FIELD study.
  (Scott R, et al. Diabetes Care. 2008 Nov 4. [Epub ahead of print])
  View Abstract
• Adiponectin normalization: a clue to the anti-metabolic syndrome action of rimonabant.
  (Maynadier M, et al. Drug Discov Today. 2008 Nov 10. [Epub ahead of print])
  View Abstract
• Platelet reactivity and response to aspirin in subjects with the metabolic syndrome.
  (Vaduganathan M, et al. Am Heart J. 2008 Nov;156(5):1002.e1-1002.e7.)
  View Abstract
• Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy.
  (Westerweel PE, et al. Eur Heart J. 2008 Nov;29(22):2808-17. Epub 2008 Sep 28.)
  View Abstract

> Back to Top

Epidemiology

• Individual and area-based indicators of acculturation and the metabolic syndrome among low-income Mexican American women living in a border region.
  (Espinosa de Los Monteros K, et al. Am J Public Health. 2008 Nov;98(11):1979-86. Epub 2008 Sep 17.)
  View Abstract
• Development and validation of an instrument to measure family physicians' clinical aptitude in metabolic syndrome in Mexico.
  (Cabrera-Pivaral CE, et al. Salud Publica Mex. 2008 Nov-Dec;50(6):457-62.)
  View Abstract

> Back to Top

Exercise & Physical Activity

• The Italian Diabetes and Exercise Study (IDES): design and methods for a prospective Italian multicentre trial of intensive lifestyle intervention in people with type 2 diabetes and the metabolic syndrome.
  (Balducci S, et al. Nutr Metab Cardiovasc Dis. 2008 Nov;18(9):585-95. Epub 2007 Dec 3.)
  View Abstract

> Back to Top

Genetics

• Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study.
  (de Mello VD, et al. Diabetologia. 2008 Nov;51(11):2060-7. Epub 2008 Aug 30.)
  View Abstract
• Associations of the estrogen receptors 1 and 2 gene polymorphisms with the metabolic syndrome in women.
  (Goulart AC, et al. Metab Syndr Relat Disord. 2008 Nov 25. [Epub ahead of print])
  View Abstract
• QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the Hypertension Genetic Epidemiology Network Study.
  (Kraja AT, et al. BMC Med Genet. 2008 Nov 27;9(1):103. [Epub ahead of print])
  View Abstract
• Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome.
  (Palatini P, et al. Am J Hypertens. 2008 Nov 20. [Epub ahead of print])
  View Abstract
• Association between BBS6/MKKS gene polymorphisms, obesity and metabolic syndrome in the Greek population.
  (Rouskas K, et al. Int J Obes (Lond). 2008 Nov;32(11):1618-25. Epub 2008 Sep 23.)
  View Abstract
• Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest.
  (Szabo de Edelenyi F, et al. Genes Nutr. 2008 Dec;3(3-4):173-6. Epub 2008 Nov 26.)
  View Abstract
• Metabolic syndrome: from epidemiology to systems biology.
  (Lusis AJ, et al. Nat Rev Genet. 2008 Nov;9(11):819-30. Review.)
  View Abstract
• Metabolic syndrome, diabetes and atherosclerosis: Influence of gene-environment interaction.
  (Andreassi MG. Mutat Res. 2008 Nov 5. [Epub ahead of print])
  View Abstract

> Back to Top

Hypertension

• Metabolic syndrome affects cardiovascular risk profile and response to treatment in hypertensive postmenopausal women.
  (Rossi R, et al. Hypertension. 2008 Nov;52(5):865-72. Epub 2008 Oct 13.)
  View Abstract
• Relationships between metabolic syndrome and left ventricular mass in hypertensive patients: does sex matter?
  (Mulè G, et al. J Hum Hypertens. 2008 Nov;22(11):788-95. Epub 2008 Jul 3.)
  View Abstract
• Hypertensive waist: First step of the screening for metabolic syndrome.
  (Nita C, et al. Metab Syndr Relat Disord. 2008 Nov 25. [Epub ahead of print])
  View Abstract

> Back to Top

Metabolic Syndrome in Men

• Hopelessness -- novel facet of the metabolic syndrome in men.
  (Valtonen M, et al. Scand J Public Health. 2008 Nov;36(8):795-802.)
  View Abstract
• Prevalence and determinants of metabolic syndrome according to three definitions in middle-aged chinese men.
  (Villegas R, et al. Metab Syndr Relat Disord. 2008 Nov 25. [Epub ahead of print])
  View Abstract

> Back to Top

Obesity

• Abdominal obesity is essential for the risk of venous thromboembolism in the metabolic syndrome - the Tromsø study.
  (Borch KH, et al. J Thromb Haemost. 2008 Nov 22. [Epub ahead of print])
  View Abstract
• Impact of laparoscopic Roux-en-Y gastric bypass on metabolic syndrome, inflammation, and insulin resistance in super versus morbidly obese women.
  (Iannelli A, et al. Obes Surg. 2008 Nov 19. [Epub ahead of print])
  View Abstract
• Obesity and the metabolic syndrome in developing countries.
  (Misra A, et al. J Clin Endocrinol Metab. 2008 Nov;93(11 Suppl 1):S9-30.)
  View Abstract
• Neck circumference as a measure of central obesity: Associations with metabolic syndrome and obstructive sleep apnea syndrome beyond waist circumference.
  (Onat A, et al. Clin Nutr. 2008 Nov 14. [Epub ahead of print])
  View Abstract
• Retinol-binding protein 4, visceral fat, and the metabolic syndrome: effects of weight loss.
  (Tschoner A, et al. Obesity (Silver Spring). 2008 Nov;16(11):2439-44. Epub 2008 Aug 14.)
  View Abstract
• Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels.
  (Demerath EW, et al. Am J Clin Nutr. 2008 Nov;88(5):1263-71.)
  View Abstract
• Independent influence of insulin, catecholamines, and thyroid hormones on metabolic syndrome.
  (De Pergola G, et al. Obesity (Silver Spring). 2008 Nov;16(11):2405-11. Epub 2008 Aug 14.)
  View Abstract
• Metabolic syndrome and insulin resistance significantly correlate with body mass index.
  (Esteghamati A, et al. Arch Med Res. 2008 Nov;39(8):803-8.)
  View Abstract
• Waist circumference alone predicts insulin resistance as good as the metabolic syndrome in elderly women.
  (Nilsson G, et al. Eur J Intern Med. 2008 Nov;19(7):520-6. Epub 2008 Apr 2.)
  View Abstract

> Back to Top

Pediatrics

• Does low birth weight predict obesity/overweight and metabolic syndrome in elementary school children?
  (Hirschler V, et al. Arch Med Res. 2008 Nov;39(8):796-802.)
  View Abstract
• Short- and long-term relationships of serum ghrelin with changes in body composition and the metabolic syndrome in prepubescent obese children following two different weight loss programmes.
  (Kelishadi R, et al. Clin Endocrinol (Oxf). 2008 Nov;69(5):721-9. Epub 2008 Feb 11.)
  View Abstract
• Ethnic differences in metabolic syndrome among overweight and obese children and adolescents: the Oslo Adiposity Intervention Study.
  (Kolsgaard ML, et al. Acta Paediatr. 2008 Nov;97(11):1557-63. Epub 2008 Jul 24.)
  View Abstract
• Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss.
  (Reinehr T, et al. J Clin Endocrinol Metab. 2008 Nov;93(11):4479-85. Epub 2008 Aug 26.)
  View Abstract
• Metabolic syndrome among prepubertal Brazilian schoolchildren.
  (Strufaldi MW, et al. Diab Vasc Dis Res. 2008 Nov;5(4):291-7.)
  View Abstract
• Adipokines and the prediction of the accumulation of cardiovascular risk factors or the presence of metabolic syndrome in elementary school children.
  (Yoshinaga M, et al. Circ J. 2008 Nov;72(11):1874-8. Epub 2008 Sep 24.)
  View Abstract
• Analysis of the relationship of leptin, high-sensitivity C-reactive protein, adiponectin, insulin, and uric acid to metabolic syndrome in lean, overweight, and obese young females.
  (Abdullah AR, et al. Metab Syndr Relat Disord. 2008 Nov 24. [Epub ahead of print])
  View Abstract
• Predicting adult metabolic syndrome from childhood body mass index: Follow-up of the New Delhi birth cohort.
  (Sachdev HS, et al. Arch Dis Child. 2008 Nov 17. [Epub ahead of print])
  View Abstract
• Prevalence of metabolic syndrome at age 16 using the International Diabetes Federation paediatric definition.
  (Pirkola J, et al. Arch Dis Child. 2008 Nov;93(11):945-51. Epub 2008 May 2.)
  View Abstract

> Back to Top

Psychological Disorders

• Equally increased risk for metabolic syndrome in patients with bipolar disorder and schizophrenia treated with second-generation antipsychotics.
  (Correll CU, et al. Bipolar Disord. 2008 Nov;10(7):788-97.)
  View Abstract
• Depressive symptoms and metabolic syndrome: is inflammation the underlying link?
  (Capuron L, et al. Biol Psychiatry. 2008 Nov 15;64(10):896-900. Epub 2008 Jul 2.)
  View Abstract
• Individual and neighborhood socioeconomic status characteristics and prevalence of metabolic syndrome: the Atherosclerosis Risk in Communities (ARIC) Study.
  (Chichlowska KL, et al. Psychosom Med. 2008 Nov;70(9):986-92. Epub 2008 Sep 16.)
  View Abstract
• Depressive symptoms predispose females to metabolic syndrome: a 7-year follow-up study.
  (Vanhala M, et al. Acta Psychiatr Scand. 2008 Nov 11. [Epub ahead of print])
  View Abstract
• Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts.
  (Vuksan-Cusa B, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Nov 12. [Epub ahead of print])
  View Abstract
• Association of metabolic syndrome with depression and anxiety in Japanese men.
  (Takeuchi T, et al. Diabetes Metab. 2008 Nov 27. [Epub ahead of print])
  View Abstract

> Back to Top

Renal Function

• Serum retinol-binding protein concentration and its association with components of the uremic metabolic syndrome in nondiabetic patients with chronic kidney disease stage 5.
  (Axelsson J, et al. Am J Nephrol. 2008 Nov 21;29(5):447-453. [Epub ahead of print])
  View Abstract
• Glomerular hyperfiltration and metabolic syndrome: results from the FIrenze-BAgno A Ripoli (FIBAR) Study.
  (Monami M, et al. Acta Diabetol. 2008 Nov 7. [Epub ahead of print])
  View Abstract
• Nodular glomerulosclerosis in a patient with metabolic syndrome without diabetes.
  (Souraty P, et al. Nat Clin Pract Nephrol. 2008 Nov;4(11):639-42. Epub 2008 Sep 16.)
  View Abstract

> Back to Top

Risk Factors

• Periodontal status of patients with metabolic syndrome compared to those without metabolic syndrome.
  (Khader Y, et al. J Periodontol. 2008 Nov;79(11):2048-53.)
  View Abstract
• Fasting serum total ghrelin level inversely correlates with metabolic syndrome in hemodialysis patients.
  (Lee CC, et al. Arch Med Res. 2008 Nov;39(8):785-90.)
  View Abstract
• Prevalence of metabolic syndrome and associated risk factors in Illinois.
  (Reppert A, et al. Am J Health Promot. 2008 Nov-Dec;23(2):130-8.)
  View Abstract
• Clinical study of the risk factors of insulin resistance and metabolic syndrome after kidney transplantation.
  (Sui W, et al. Transpl Immunol. 2008 Nov;20(1-2):95-8. Epub 2008 Aug 12.)
  View Abstract
• Albuminuria, but not metabolic syndrome, is a significant predictor of stroke recurrence in ischemic stroke.
  (Yokota C, et al. J Neurol Sci. 2008 Nov 6. [Epub ahead of print])
  View Abstract
• Metabolic syndrome in liver transplantation: relation to etiology and immunosuppression.
  (Bianchi G, et al. Liver Transpl. 2008 Nov;14(11):1648-54.)
  View Abstract
• Alanine aminotransferase and gamma-glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosis.
  (Saely CH, et al. Clin Chim Acta. 2008 Nov;397(1-2):82-6. Epub 2008 Jul 29.)
  View Abstract
• Relationship between brachial artery flow-mediated dilatation, hyperemic shear stress, and the metabolic syndrome.
  (Title LM, et al. Vasc Med. 2008 Nov;13(4):263-70.)
  View Abstract
• 20-HETE and F(2)-isoprostanes in the metabolic syndrome: the effect of weight reduction.
  (Tsai IJ, et al. Free Radic Biol Med. 2008 Nov 1. [Epub ahead of print])
  View Abstract
• Serum nitric oxide metabolites in subjects with metabolic syndrome.
  (Zahedi Asl S, et al. Clin Biochem. 2008 Nov;41(16-17):1342-7. Epub 2008 Sep 3.)
  View Abstract

> Back to Top

Sleep Disorders

• Visceral obesity is associated with the metabolic syndrome and elevated plasma retinol binding protein-4 level in obstructive sleep apnea syndrome.
  (Makino S, et al. Horm Metab Res. 2008 Nov 10. [Epub ahead of print])
  View Abstract

> Back to Top

Vascular Biology

• Potent and selective PPAR-{alpha} agonist LY518674 upregulates both apoA-I production and catabolism in human subjects with the metabolic syndrome.
  (Millar JS, et al. Arterioscler Thromb Vasc Biol. 2008 Nov 6. [Epub ahead of print])
  View Abstract
• Plasma total antioxidant activity in comparison with plasma NO and VEGF levels in patients with metabolic syndrome.
  (Barylski M, et al. Angiology. 2008 Nov 17. [Epub ahead of print])
  View Abstract
• r-metHuLeptin does not improve HAART-induced lipoatrophy and the metabolic syndrome through altering circulating IGF and IGF binding protein levels: observational and interventional studies in humans.
  (Brennan A, et al. Eur J Endocrinol. 2008 Nov 24. [Epub ahead of print])
  View Abstract

> Back to Top